Also has place were HD genetics testing can be ordered.
and Newcombe have calculated the following table of age-specific
Bayesian risks for asymptomatic (as confirmed by neurological
individuals at a 50% prior risk of HD.
It is important to note that clinical status can only be assessed via
exam; asymptomatic status should not be assumed without assessment by a
neurologist. For example, the risk
of HD for an at-risk individual who is
asymptomatic at 60 years of age is reduced to 18.7% from 50%. Bayesian
is less pronounced with younger, asymptomatic patients.
||Probability of an|
This family pedigree illustrates the inheritance of the IT15 HD mutation
and how various individuals are affected by a positive diagnosis in the family. Two aspects of the disease are examined in
selected family members: the individual's risk of possessing a mutation and psychosocial considerations, including genetic
counseling. Click on a circle or square, representing a family member in the pedigree below, to learn of that person's unique
circumstances involving HD.
|The above pedigree is entirely fictional. Comments regarding
psychosocial considerations are intended to represent probable situations and may not be applicable to all patients or families.|
Click on individuals in the pedigree
to learn more. A new browser window will open with details on that individual.