Athena/NeuroCast
http://staging26.newtonline.com/site/content/sessions_10_2000.shtml
Also has place were HD genetics testing can be ordered.
Harper
and Newcombe have calculated the following table of age-specific
Bayesian risks for asymptomatic (as confirmed by neurological
exam)
individuals at a 50% prior risk of HD.
It is important to note that clinical status can only be assessed via
neurological
exam; asymptomatic status should not be assumed without assessment by a
neurologist. For example, the risk
of HD for an at-risk individual who is
asymptomatic at 60 years of age is reduced to 18.7% from 50%. Bayesian
risk modification
is less pronounced with younger, asymptomatic patients.
| Age (Years) |
Probability of an
HD mutation(%) |
| 20.0 |
49.6 |
| 22.5 |
49.3 |
| 25.0 |
49.0 |
| 27.5 |
48.4 |
| 30.0 |
47.6 |
| 32.5 |
46.6 |
| 35.0 |
45.5 |
| 37.5 |
44.2 |
| 40.0 |
42.5 |
| 42.5 |
40.3 |
| 45.0 |
37.8 |
| 47.5 |
34.8 |
| 50.0 |
31.5 |
| 52.5 |
27.8 |
| 55.0 |
24.8 |
| 57.5 |
22.1 |
| 60.0 |
18.7 |
| 62.5 |
15.2 |
| 65.0 |
12.8 |
| 67.5 |
10.8 |
| 70.0 |
6.2 |
| 72.5 |
4.6 |
This family pedigree illustrates the inheritance of the IT15 HD mutation
and how various individuals are affected by a positive diagnosis in the family. Two aspects of the disease are examined in
selected family members: the individual's risk of possessing a mutation and psychosocial considerations, including genetic
counseling. Click on a circle or square, representing a family member in the pedigree below, to learn of that person's unique
circumstances involving HD.
| The above pedigree is entirely fictional. Comments regarding
psychosocial considerations are intended to represent probable situations and may not be applicable to all patients or families. |
Instructions:
Click on individuals in the pedigree
to learn more. A new browser window will open with details on that individual.
