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Neuroleptic
I. Indications Psychosis
(e.g. Schizophrenia)
II. Antipsychotic Agents: High Potency Fluphenazine HCl (Permitil, Prolixin)
Extrapyramidal Side effects (EPSE) Maximum Dose: 40 mg PO or 100 mg IM per day
Haloperidol (Haldol) http://www.fpnotebook.com/PSY170.htm Extrapyramidal Side effects
(EPSE) Maximum Dose: 100 mg per day Thiothixene HCl (Navane)
Extrapyramidal Side effects (EPSE) Maximum Dose: 60 mg per day
Pimozide (Orap) Trifluoperazine (Stelazine)
III. Antipsychotic Agents: Medium Potency
Droperidol (Inapsine) Loxapine (Loxitane) Molindone (Moban)
Perphenazine (Trilafon)
IV. Antipsychotic Agents: Low Potency Chlorpromazine HCl (Thorazine)
Anticholinergic Symptoms Alpha adrenergic blockade (Hypotension)
Sedation Maximum dose: 1000 mg per day Thioridazine HCl
(Mellaril) Anticholinergic Symptoms
alpha adrenergic blockade (Hypotension) Sedation
Maximum Dose: 800 mg per day Mesoridazine
IV. Atypical Antipsychotics: Serotonin>Dopamine
Antagonists Dibenzodiazepine (Clozapine, Clozaril) Anticholinergic
Symptoms alpha adrenergic blockade (Hypotension)
Sedation Maximum Dose: 900 mg per day Olanzapine (Zyprexa)
Quetiapine (Seroquel) Risperidone (Risperdal) Ziprasidone (Geodon)
Anticholinergic
Toxicity Symptoms
Causes See Anticholinergic Medications Antihistamines
Tricyclic Antidepressants Incapacitating Agents: BZ Ingested items
Jimsonweed Amanita muscaria mushrooms Parasympatholytic
medications Atropine Scopalamine
Hyoscyamine
Symptoms: Mneumonic (antimuscarinic) Hot as a hare (Hyperthermia)
Dry as a bone (Dry Skin) Red as a beet (Flushed) Blind as bat (Mydriasis)*
Mad as a hatter (Delirium)
Symptoms: Complete List (antimuscarinic) Altered Level of Consciousness
Hallucinations Delirium Coma
Seizures Tachycardia Hypertension Hyperthermia (hot, Dry
Skin) Dry Mouth Mydriasis with blurred vision Decreased
bowel sounds Constipation Urinary retention
Management
Control hyperthermia Antidote: Physostigmine (Usually contraindicated
DEFINITIONS Mydriasis-Pupil
Dilatation http://www.fpnotebook.com/EYE35.htmXerostomia- Dry Mouth http://www.fpnotebook.com/DEN23.htmEcholalia or ecopraxia (Echophenomena _
Repeating other person's words or statements Imitating other peron's actions Repeating
patient's own statements
Serotonin http://www.fpnotebook.com/PSY103.htm Psychosis http://www.fpnotebook.com/PSY178.htm Huntington's chorea http://www.fpnotebook.com/NEU5.htm Personality Disorder http://www.fpnotebook.com/PSY19.htm Mood Disorder http://www.fpnotebook.com/PSY80.htm Major Depression http://www.fpnotebook.com/PSY50.htm Medical Conditions Predisposing
to Depression Alzheimer's Disease or other Dementia
Cancer Chronic Fatigue Syndrome http://www.fpnotebook.com/RHE117.htm
Chronic Pain Syndrome http://www.fpnotebook.com/RHE77.htm
Coronary Artery Disease Crohn's Disease
Medications Predisposing to Depression Diabetes Mellitus
Fibromyalgia http://www.fpnotebook.com/RHE61.htm
Parkinson's Disease Cerebrovascular Accident (CVA)
Negative Symptoms in Psychosis
http://www.fpnotebook.com/PSY180.htm Emotional withdrawal Poor
rapport Alogia Anergia Social withdrawal
Blunt affect Lack of spontaneity and flow of conversation Stereotyped thinking
Attentional Impairment Poor abstraction Avolition-apathy
Anhedonia
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