Subtle changes among presymptomatic HD Among Huntington's disease gene carriers, subtle cognitive and motor deficits precede the onset of sufficient neurological abnormality to warrant a clinical diagnosis of Huntington's disease.   Clinical markers of early disease HD Neuropsychological measures show impairment 2 years before the development of more manifest motor disease. Findings suggest that these brief cognitive measures administered over time may capture early striatal neural loss in HD.   Retest effects and cognitive decline in early HD. Many attention and executive tasks adequately assess the progression of the disease at an early stage. For other functions, the overlapping of retest effects and disease progression may confuse the results. High interindividual and intraindividual variability seem to be hallmarks of the disease.   Cognitive Testing Detects Early Huntington's Disease "Early signs of Huntington's disease can be detected using neuropsychological measures 2 years before the development of more manifest motor disease," Dr. Jane S. Paulsen of the University of Iowa, Iowa City, tells Reuters Health.   Chorea-Adults One of the best description on causes, symptoms, testing,treatment and medications.