Clinical Trials & Research

Clinical Trials and On-going Research

A clinical trial (study) is the most effective method for estimating the medical value of promising treatments. By design, it provides the necessary confidence and safeguards for learning whether medications do what they are supposed to do.

There are also observational studies or trials where people are examined periodically but receive no experimental drugs or treatments. Below is a listing of clinical trials and on-going research.

For a more complete list of clinical trials for HD and other diseases, go to the National Institutes of Health (NIH) database of clinical trials listed by service at CenterWatch..

HD Research Roster
Huntington Study Group (HSG)
Pharos Study
Riluzole Dosing in HD (RID HD)
Genetic Alliance Study on Genetic Discrimination and Privacy Abuse
Transplantation Surgery Still Experimental
CoQ10 article

Clinical Trials-HD Center of Excellence Iowa
Research (click) Clinical trials

PHAROS (Pilot Huntington's At-Risk Observational Study)
EMOTIONAL REGULATION OF PATIENTS WITH BRAIN INJURY
GENERAL HD BATTERY
FMRI Functional Magnetic Resonance Imaging (fMRI) scanning
Motor Assessment Battery

Clinical Trials - Indiana University
Pilot Huntington At Risk Observational Study (PHAROS)
http://www.iupui.edu/~medgen/research/hd/pharos/pharos.html

Coloroda Neurological Institute
Huntington's - PHAROS

(PHAROS (Pilot Huntington At Risk Observational Study)

TREATMENTS-

From Sanford University's HOPE program for HD
http://www.stanford.edu/group/hopes/

Towards Finding A Cure: An Introduction to HD Drugs and Supplements

Compounds to remove protein build-up

Anti-inflammatory agents

Compounds that increase energy available to cells

Antioxidant therapies

Anti-glutamate therapies

GABAergic approaches

Gene transcription regulators

Other neuroprotective compounds

OTHER

Clinical Trials - Huntington's Disease Society of America

Clinical Trials and On-going Research - Hereditary Disease Foundation

Clinical Trials - Huntington's Disease - CenterWatch

Huntington Disease - ClinicalTrials.gov

Huntington's Disease Research Roster - Hereditary Disease Foundation

The HD Research Roster computerizes the names of families, including information about the history of HD in the family (family trees) and other related data. This information identifies HD patients and families who are interested in participating in rese.arch projects

Huntington's Disease: Research Update Sept. 98 -Dr. Longo suggested that known drugs that cross the blood brain barrier

New Treatment Strategies - Tetsuo Ashizawa, MD

Remacemide/Coenzyme Q10 Have Inconclusive Effect on Progression of Huntington?s Disease

Review of Publications in the Last Year Relating to Huntington's Disease Excellent resentation by Dr. Kathleen Shannon at the General Meeting
of the Illinois Chapter, Huntington's Disease Society of America,
March 8, 1997.

Remacemide/Coenzyme Q10 Have Inconclusive Effect on Progression

of Huntington?s Disease- August 2001 press release on a clinical trial of two experimental drugs for Huntington's disease. National Institute of Neurological Disorder

RESEARCH

Also see the HD Lighthouse http://www.hdlighthouse.org and HDAC's www.hdac.org websites for current updates on Research in HD.

Advances in Understanding of the Disease Mechanisms - Tetsuo Ashizawa, MD

Early Postoperative Results in Ten Huntington's Disease Patients Following

Transplantation of Fetal Striatal Tissue - Kaaren Eagle, MD

HSG Position Statement on Experimental Surgical Treatments in HD

- Huntington Study Group

Latest Research - Huntington's Disease Society of America

News and Articles - Hereditary Disease Foundation

Huntington's Disease: Hope Through Research
An information booklet on Huntington's disease compiled by the National Institute of Neurological Disorders and Stroke (NINDS).
http://www.ninds.nih.gov/health_and_medical/pubs/huntington_disease-htr.htm

Scientists Identify Potential New Treatment for Huntington's Disease
February 2002 news summary on a possible new treatment for Huntington's disease (HD). A drug called cystamine alleviates tremors. http://www.ninds.nih.gov/news_and_events/news_article_huntington_cystamine.htm

What Research is Being Done? -

National Institute of Neurological Disorders and Stroke