Disturbances in Homeostatic Functions
The following disturbances do not have specific treatments, but
are mentioned here because they can be a source of puzzlement
Throughout the illness, some patients perspire excessively and
become hungrier and more thirsty. Some patients become intolerable
to changes in ambient temperature, insisting that the temperature is
either too high or too low.
Disturbances of temperature and blood pressure can be particularly severe in later stages of the disease when patients may have episodes that resemble Neuroleptic Malignent Symdrome (NMS) in the absence of neuroleptic medication.
Menstrual irregularities hav ealso been reported. The biological basis for osuch disturbances has not been established, although some have implicated the hypothalus which has been demonstrated to undergo neuronal loss in HD.
Menstrual Cycle and Seizures?
Denise also had seizures during her menstrual cycles but i always attributed it to her not feeling well. She also had them if she had a cold, the flu or just didnt feell good. I also noticed that if she was overtired she would have them.
Maybe it's a thing with juvenile HD females? Any time Kelly was sick, over tired or on her menstrual cycle her chorea worsened, which made her excitability level rise, which if not contained (valium or calming) would lead to hyperventilation and seizures. At first the neuro (Dr. H) looked at me like I was from Mars when I wanted her hormone levels measured before and after her periods as I felt they were highly elevated during them. He, nor her primary care physician, would ever do the testing (a simple blood test).
A few years later when Kelly had an appointment with Dr.H and her feet were dangerous weapons, flying out constantly, he wanted it noted her chorea had worsened. As gentle as I could, with my teeth clenched, I reminded him that she ALWAYS got that way during her periods and I wanted her hormones checked.
At that time he said someone was doing a study on that, to see whether females with HD had more difficulty during their periods. I never learned anything about this study or it's outcome.
October 16, 2001 - Related?
Epilepsy Studies: Volunteers Needed
Hormonal Therapy for Women with Epilepsy Physicians in the Cleveland Clinic Epilepsy Center are studying the use of progesterone in women who have seizures related to the female reproductive cycle and are incompletely controlled with standard antiepileptic drugs. Participants should be at least age 16 and have an average monthly seizure frequency of at least 4 seizures. Participants also must not be taking hormone medications. For more information, contact Silvia Neme, MD, or Nancy Foldvary, DO, at 216/445-2990 or 800/223-2273 ext. 52990.